Dr. Kyle Gillett: Tools For Hormone Optimization In Males | Huberman Lab Podcast 102 [6ae54d]
2025-07-30
Post Time: 2025-07-30
## Understanding Cialis and Its Use **Cialis**, known generically as **tadalafil**, is a medication primarily used to treat **erectile dysfunction (ED)** and the symptoms of **benign prostatic hyperplasia (BPH)**. It belongs to a class of drugs called **PDE5 inhibitors**, which work by increasing blood flow to the penis, facilitating an erection when sexually stimulated. Unlike some other ED medications, Cialis is known for its long duration of action, often referred to as the "weekend pill," as its effects can last up to 36 hours. This characteristic makes it a popular choice for individuals seeking flexibility in their sexual activity. Understanding its mechanism of action and typical uses is crucial for safe and effective long-term use. ## Initial Dosage Considerations The starting dose of Cialis usually depends on the individual's specific needs and health conditions. For ED, the most common starting dose is **10 mg**, taken as needed, at least 30 minutes prior to sexual activity. This dose can be adjusted based on response and tolerance. Some individuals may find 5 mg effective, while others may require 20 mg. The initial dosage considerations should involve a conversation with a healthcare provider to determine the most appropriate starting point. It is imperative to avoid adjusting your dosage without medical advice. For BPH, the starting dose is often 5 mg daily, with minimal adjustments in the dose made based on clinical evaluation. ## Long-Term Dosage Adjustments and Management Long-term use of Cialis requires careful consideration and adjustments in dosage. Patients must be monitored to ensure they are using the most effective dose and experiencing minimal side effects. Regular consultations with healthcare providers can help optimize long-term treatment plans. The dosage is not fixed and can be adjusted based on the patient’s response and tolerability, taking into account efficacy and side effect profiles. Typically, the dosage is optimized to provide effectiveness and maintain a satisfactory tolerability for prolonged use. Some patients may start with on-demand dosing initially, but might switch to daily low dose Cialis if they prefer more spontaneous sexual activity. ## Common Cialis Dosages | Dosage | Purpose | Typical Frequency | Comments | |---------------|--------------------------------------|-------------------|-------------------------------------------------------------------------| | **2.5 mg** | Daily use for ED/BPH | Daily | Lowest dose, suitable for daily use; may minimize side effects | | **5 mg** | Daily use for ED/BPH; as needed for ED| Daily or as needed | Often a starting point for daily use; can also be used on demand | | **10 mg** | On-demand for ED | As needed | Common starting dose for ED, typically taken before sexual activity | | **20 mg** | On-demand for ED | As needed | Higher dose for individuals who don't respond well to lower doses | ## Monitoring and Potential Side Effects Long-term Cialis usage can come with potential side effects, and proactive monitoring is essential. Common side effects include **headaches, flushing, nasal congestion, and indigestion**. More rarely, some people experience back pain, muscle aches, and visual disturbances. Individuals should report any persistent or severe side effects to their healthcare provider. It's important to ensure there are no drug interactions with other medications one is taking. Regular health check-ups while on long-term Cialis can help in the early detection and management of potential side effects, which helps ensure long-term treatment adherence. My guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We discuss how to optimize male hormones using a range of nutritional and behavioral tools, exercise, and supplementation (including discussions on tongkat ali, fadogia agrestis, creatine, peptides and more). We explain how puberty and aging affect hormone levels, how to use bloodwork to monitor hormone levels, how hormone health impacts fertility, libido, hair loss, and prostate health, and describe behaviors that negatively impact testosterone levels. We also discuss how to approach prescription hormone therapies, including which does magnum tonic wine contain viagra biomarkers to monitor when using these approaches and how to optimize synergistic hormones (e.g., growth hormone and thyroid hormone) to support complete hormone health safely and rationally. Dr. Gillett offers numerous actionable tools that can be tailored to specific goals and age ranges to attain and maintain optimal levels of male hormones for overall health, well-being and longevity. #HubermanLab viagra trial free #Science #Hormones Thank you to our sponsors AG1 (Athletic Greens): Thesis: ROKA: Helix Sleep: InsideTracker: Huberman Lab Premium Social & Website Instagram: Twitter: Facebook: TikTok: LinkedIn: Website: Newsletter: Dr. Kyle Gillet Dr. Gillett’s clinic: Gillet Health YouTube channel: The Gillet Health Podcast on Spotify: The Gillet Health Podcast on Apple Podcasts: Instagram: Twitter: Timestamps 00:00:00 Dr. Kyle Gillett & Male Hormone Optimization 00:03:40 Thesis, ROKA, Helix Sleep, Momentous 00:07:43 Puberty: Height, Resistance Training, Childhood Obesity 00:15:14 “First” vs. “Second” Puberty 00:17:17 Hormone Optimization & Blood Work 00:22:14 Diet, Exercise, Sleep & Hormones 00:28:23 Hormones, Stress, Social Connection & Purpose 00:32:19 Hormones, Supplementation & Medication 00:34:08 Determining Individual Hormone Levels, ADAM Questionnaire 00:40:35 Libido, Masturbation, Pornography & the Dopamine “Wave Pool” 00:48:32 AG1 (Athletic Greens) 00:49:46 Sustainable Exercise Regimen for Hormone Health 00:58:12 Testosterone Replacement Therapy (TRT) 01:01:02 Supplementation: Creatine & Hair Loss, Betaine, L-Carnitine & Allicin (Garlic) 01:11:45 Vitamin D, Boron; SHBG & Free Testosterone 01:15:34 InsideTracker 01:16:39 Tongkat Ali (Eurycoma longifolia; Longjack) & Steroid Pathways 01:22:09 Fadogia Agrestis & Testosterone 01:26:32 Optimize Growth Hormone & IGF-1: Diet, Fasting, Supplements & Exercise 01:31:52 Optimize Thyroid Hormone: Iodine & Goitrogens 01:33:56 Peptides: Growth Hormone, Tesamorelin, Ibutamoren & Gut Microbiome 01:42:06 Testosterone Therapy 01:47:03 Prescriptions & Hormones: Human Choriogonadotropin (HCG), Clomiphene 01:52:56 Testosterone Therapy + HCG, Fertility & Temperature 01:55:30 Hormone Health Q&A: Marijuana, Nicotine, Cycling, Pelvic Floor, Alcohol, Fat 02:06:08 Prostate Health & Tadalafil, Prostate Specific Antigen (PSA) 02:09:56 Hair Loss & DHT; Turmeric & Curcuminoids 02:18:13 BPAs, Phthalates & Hormone Health 02:21:55 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network Newsletter The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, does viagra low blood pressure diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac -