How To Perform Penile Injection For Erectile Dysfunction (Graphic) [be4cdd]
2025-07-30
Post Time: 2025-07-30
**Avanafil**, commonly known by the brand name **Stendra**, is a relatively newer medication in the arsenal of treatments for **erectile dysfunction (ED)**. What distinguishes it from other **PDE5 inhibitors** like **sildenafil (Viagra)**, **tadalafil (Cialis)**, and **vardenafil (Levitra)** is its rapid onset of action and its ability to provide relief with a potentially lower incidence of side effects. This article explores the detailed aspects of avanafil, its mechanism of action, effectiveness, and considerations for use. ## The Science Behind Avanafil: How Does it Work? **Erectile dysfunction** is often caused by insufficient blood flow to the penis. **Avanafil** combats this by inhibiting the enzyme **phosphodiesterase type 5 (PDE5)**, which is responsible for breaking down **cyclic guanosine monophosphate (cGMP)** in the smooth muscle cells of the penis. When sexual stimulation occurs, the body releases nitric oxide, leading to increased cGMP levels. This relaxation of smooth muscles results in increased blood flow into the penis, facilitating an erection. By blocking the action of PDE5, avanafil helps maintain higher levels of cGMP, prolonging smooth muscle relaxation, and making it easier to achieve and sustain an erection. What makes avanafil unique is that it is engineered to be highly selective for PDE5, reducing the likelihood of impacting other PDE enzymes found throughout the body, and thus, minimizing potential side effects. Here's a table summarizing the key aspects of avanafil's action: | Feature | Description | Significance | | -------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------ | | **Target Enzyme** | **Phosphodiesterase type 5 (PDE5)** | Selective action enhances efficacy while reducing the chance of off-target effects. | | **Mechanism** | Inhibits the breakdown of **cyclic GMP (cGMP)**, which is crucial for smooth muscle relaxation in the penis | Increased cGMP levels allow for better blood flow and improved erectile function. | | **Onset of Action** | Rapid, typically within 15-30 minutes | Allows for greater spontaneity in sexual activity compared to other medications. | ## Efficacy and Onset of Action: How Fast Does It Work? One of the major advantages of **avanafil** is its rapid onset of action. Clinical trials have consistently shown that avanafil can achieve effectiveness in as little as 15 minutes after ingestion. This is significantly faster than other PDE5 inhibitors, such as **sildenafil** and **vardenafil**, which typically require around 30-60 minutes to take effect. **Tadalafil**, another PDE5 inhibitor, is known for its longer duration of action but has a slower onset compared to **avanafil**. This fast-acting characteristic of avanafil is a considerable benefit for men seeking a more spontaneous sexual experience. Furthermore, avanafil provides a good balance between fast action and effective duration. While not as long-lasting as **tadalafil**, avanafil can be effective for approximately 4-6 hours. This window of effectiveness allows for a comfortable and reasonable duration for sexual activity. A summary of the onset and duration of common ED medications is listed below: | Medication | Onset of Action | Duration of Effect | |------------|----------------------|-----------------------| | Avanafil | 15-30 minutes | 4-6 hours | | Sildenafil | 30-60 minutes | 3-4 hours | | Tadalafil | 30-60 minutes | Up to 36 hours | | Vardenafil | 30-60 minutes | 4-5 hours | ## Dosage and Usage Considerations **Avanafil** is available in different strengths, typically ranging from 50mg to 200mg. The appropriate dosage is usually determined by an individual’s overall health, response to treatment, and the presence of other medications. It’s crucial to consult with a healthcare professional to determine the ideal starting dose. Key factors influencing dosage: * **General health conditions**: Individuals with liver or kidney issues may require dosage adjustments. * **Concurrent medications**: Certain medications can interact with avanafil and affect its effectiveness or side effect profile. * **Previous ED treatment**: Prior experience with other PDE5 inhibitors can inform the appropriate avanafil dose. **Administration Instructions:** * Avanafil is taken orally, ideally 15-30 minutes before anticipated sexual activity. * It can be taken with or without food. However, high-fat meals may slightly delay the onset of action. * Avoid taking avanafil more than once within a 24-hour period to reduce the risk of adverse effects. * For optimal results, sexual stimulation is necessary for avanafil to facilitate an erection. ## Side Effects and Safety Profile While **avanafil** is generally well-tolerated, like any medication, it can cause side effects. However, due to its selectivity for PDE5, avanafil is believed to be less likely to produce certain side effects that may be associated with other PDE5 inhibitors. Common side effects may include: * **Headache** * **Flushing** * **Nasal congestion** * **Dizziness** Less common and more serious side effects may include: * **Changes in vision** * **Hearing problems** * **Priapism (a prolonged and painful erection)** If any of these less common or serious effects occur, medical attention should be sought immediately. Individuals with a history of heart conditions or those using certain medications like nitrates should avoid using **avanafil** because of potential risks. A summary table of potential side effects based on clinical studies: | Side Effect | Incidence Rate | Severity | |---------------------|-----------------|-----------| | Headache | 10-15% | Mild to Moderate | | Flushing | 8-12% | Mild to Moderate | | Nasal Congestion | 5-10% | Mild | | Dizziness | 3-7% | Mild | | Visual Disturbances | Less than 1% | Serious | | Priapism | Less than 1% | Serious | *Note: Incidence rates are approximate and can vary between individuals. Consult with a healthcare professional for personalized advice.* ## Avanafil vs. Other ED Medications To fully understand the benefits of **avanafil**, it is helpful to compare it directly with other commonly used **PDE5 inhibitors**. Here's a breakdown: | Feature | Avanafil (Stendra) | Sildenafil (Viagra) | Tadalafil (Cialis) | Vardenafil (Levitra) | |------------------------|------------------------|------------------------|------------------------|------------------------| | **Onset of Action** | 15-30 minutes | 30-60 minutes | 30-60 minutes | 30-60 minutes | | **Duration of Effect** | 4-6 hours | 3-4 hours | Up to 36 hours | 4-5 hours | | **Food Interaction** | Minimal Effect | May delay absorption | Minimal Effect | May delay absorption | | **Selectivity** | High for PDE5 | Moderately Selective | Moderately Selective | Moderately Selective | | **Side Effects** | Generally lower incidence | Moderate | Moderate | Moderate | | **Primary Use Case** | Fast onset, spontaneity | Standard use | Long duration, daily use| Standard use | **Key Takeaways:** - **Avanafil** is a favorable option for individuals seeking rapid-acting ED medication. - Its high selectivity for PDE5 contributes to a more favorable side effect profile. - While not as long-lasting as **tadalafil**, its duration is suitable for many users. - Proper usage under the guidance of a healthcare provider is crucial to achieve the best results and minimize potential risks. ## Conclusion **Avanafil (Stendra)** represents a significant advancement in the treatment of **erectile dysfunction**, offering a fast-acting and well-tolerated option for men seeking reliable relief. Its rapid onset of action enables more spontaneity, and its favorable side effect profile makes it a viable alternative for individuals who may have experienced issues with other PDE5 inhibitors. By consulting with a healthcare provider, individuals can determine whether **avanafil** is the right option for their specific needs and achieve an improved quality of life. This is essential because, while avanafil offers benefits, it should be administered responsibly and only after a comprehensive medical evaluation. Warning: This video contains health footage which may not which is the best male enhancement product be suitable for all viewers. Erectile dysfunction (ED) is a common condition that affects many men at some point in their life. Penile injections are one of several options if other treatments fail, or for men who are unable to take ED oral medication. Urologic surgeon Petar Bajic, MD, explains the technique for safe use of penile injections. If you’re not yet started on a treatment for ED and want to learn more, make an appointment with our Cleveland Clinic Men’s Health team. We’re here to help. Call 216.444.5600. Dr. Bajic genesis 6 male enhancement is the Director of the Center for Men's Health at Cleveland Clinic. To learn more what happens when you use viagra about him, please visit If you liked the video hit like and subscribe for more! #clevelandclinic #menshealth #erectiledysfunctiontreatment #erectile_dysfunction