How Much Does The Penis Enlargement Surgery Costs? - ‘’Dr. Evren ISIK’’ [7cfe5b]
2025-07-30
Post Time: 2025-07-30
**Erectile dysfunction (ED)** affects millions of men worldwide, impacting their confidence and intimate relationships. Fortunately, effective medications like **Sildenafil (Viagra)** and **Avanafil (Stendra)** are available to help manage this condition. Both belong to a class of drugs called PDE5 inhibitors but differ significantly in their onset, duration, and side effect profiles. Understanding these differences can help you and your healthcare provider choose the most suitable option. ## Title 1: Understanding the Mechanisms of Sildenafil and Avanafil Both **sildenafil** and **avanafil** work by inhibiting the phosphodiesterase type 5 (PDE5) enzyme, which plays a role in regulating blood flow to the penis. When a man is sexually stimulated, nitric oxide is released, which activates an enzyme called guanylate cyclase. This enzyme then increases the levels of cyclic guanosine monophosphate (cGMP), which causes the smooth muscles in the penis to relax. The relaxation of these muscles allows for increased blood flow into the corpus cavernosum, leading to an erection. By inhibiting PDE5, both medications boost and sustain the effect of cGMP, aiding in achieving and maintaining an erection suitable for satisfactory sexual intercourse. ### Comparative Breakdown of Mechanism | Feature | Sildenafil (Viagra) | Avanafil (Stendra) | | ------------------- | ------------------------------------------------------- | ------------------------------------------------------- | | **Mechanism** | Inhibits PDE5 to increase cGMP, promoting blood flow. | Inhibits PDE5 to increase cGMP, promoting blood flow. | | **Onset of Action** | Around 30-60 minutes. | Around 15-30 minutes. | | **Duration** | Approximately 4-5 hours. | Approximately 6-12 hours. | As shown in the table, the primary mechanism is the same but the **onset of action** and the **duration** vary which impact how one might choose one over the other. The mechanism is largely the same, both working to promote blood flow to the penis. However, their effectiveness in terms of speed and duration differs significantly. ## Title 2: A Deep Dive into Onset of Action and Duration The **onset of action** and duration of effect are two of the most critical factors men consider when choosing an ED medication. **Sildenafil**, typically taken 30-60 minutes before sexual activity, has a relatively longer time to reach its maximum effectiveness, and its duration is about 4-5 hours. In contrast, **avanafil** stands out for its faster onset, often taking effect in as little as 15 minutes, and it can last for a longer duration, ranging from 6 to 12 hours, sometimes even longer depending on dosage and individual response. ### Onset and Duration: Experimental Data | Medication | Average Onset (Minutes) | Duration of Effect (Hours) | | ----------- | --------------------- | ------------------------ | | Sildenafil | 30-60 | 4-5 | | Avanafil | 15-30 | 6-12 | These numbers are general guidelines, and individual experiences can vary based on various factors like: 1. **Metabolic Rates**: Individual differences in how the body processes medications can affect the timing and duration of action. 2. **Food Intake**: Consumption of fatty foods may delay the onset of action for both drugs but could have a more pronounced effect on sildenafil. 3. **Dosage**: The prescribed dose of either medication will play a significant role in the intensity and duration of its effects. The rapid **onset of action** for avanafil provides greater flexibility, potentially making it preferable for spontaneous sexual activity. The longer window of effectiveness can provide a more extended period of response, which may be ideal for individuals who prefer a longer window of opportunity. ## Title 3: Side Effects and Tolerability Profiles Like all medications, **sildenafil** and **avanafil** can cause side effects. While both share some common side effects, their frequency and intensity may differ. ### Common Side Effects: | Side Effect | Sildenafil (Viagra) | Avanafil (Stendra) | | ----------------- | ------------------- | ------------------ | | Headache | Common | Common | | Facial Flushing | Common | Less common | | Nasal Congestion | Common | Less common | | Dyspepsia | Common | Less common | | Visual Disturbances | Occasional | Rare | | Dizziness | Occasional | Less common | It is imperative to note that most of these side effects are mild to moderate in intensity and transient. However, the differences may help in determining the preference of one over the other. ### Key Distinctions: 1. **Visual Disturbances**: **Sildenafil** has been associated with temporary visual changes such as blurred vision or a blue tint to vision. This is considerably less common with **avanafil**. 2. **Facial Flushing and Nasal Congestion**: These are relatively more common with sildenafil than avanafil. 3. **Cardiovascular considerations**: Both medications can affect blood pressure and should be used cautiously in individuals with cardiovascular disease, making a conversation with a healthcare provider essential to determine safety and eligibility. **Avanafil** is often considered to be more selective for PDE5, which may contribute to a more favorable side effect profile compared to **sildenafil**. In clinical trials, avanafil has generally shown a lower incidence of these side effects, particularly facial flushing and visual disturbances. This makes it potentially better tolerated for some individuals. ## Title 4: Drug Interactions and Precautions Both **sildenafil** and **avanafil** can interact with other medications, which is an essential factor to consider. Nitrates, often used to treat angina, can interact dangerously with both medications, leading to a sudden drop in blood pressure, making simultaneous use contraindicated. ### Common Interactions | Medication | Interaction with Sildenafil & Avanafil | Potential Consequence | | ---------------------------------------------- | ----------------------------------- | --------------------------------------------------- | | Nitrates (e.g., nitroglycerin) | Contraindicated | Severe drop in blood pressure | | Alpha-blockers (e.g., tamsulosin) | Possible interaction, caution needed | Increased risk of hypotension or dizziness | | CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) | Increased levels of ED drugs | Increased side effects, may need dosage adjustments | **Precautions:** 1. **Medical History:** Inform your doctor about all current medications and any medical conditions, especially heart conditions, liver, or kidney issues. 2. **Grapefruit Juice:** Concurrent consumption with grapefruit or grapefruit juice can increase drug levels in the body. 3. **Alcohol:** Excessive alcohol intake may enhance side effects like dizziness and lower blood pressure. Always consult with a healthcare provider to discuss your medical history and other medications to assess the risk of any drug interactions. They will assess your specific situation to determine the most suitable and safest treatment option. ## Title 5: Choosing the Right Medication for You: Sildenafil or Avanafil Deciding between **sildenafil** and **avanafil** depends on individual preferences, lifestyle, and medical needs. Here's a comparative summary to guide the choice: | Factor | Sildenafil (Viagra) | Avanafil (Stendra) | | ----------------------- | ------------------------------------- | --------------------------------------- | | Onset of Action | 30-60 minutes | 15-30 minutes | | Duration of Effect | 4-5 hours | 6-12 hours | | Side Effects | Higher rates of flushing, visual issues | Lower rates of side effects | | Interaction with food | May be delayed with fatty meals | Not significantly affected by food | | Cost | Generally lower | Typically higher | | Spontaneity | Less | More | ### Key Considerations: 1. **Timing:** If you prefer faster onset of action for more spontaneity, **avanafil** may be more suitable. If the timing of sexual activity is more predictable, either may suffice. 2. **Side Effect Profile:** If you are prone to certain side effects like visual disturbances, **avanafil** is often better tolerated. 3. **Duration**: Individuals desiring a more extended period of response may prefer avanafil's longer window of effect. 4. **Cost:** **Sildenafil**, particularly the generic form, is often more affordable. ### Making the Decision Consulting with your healthcare provider is the most important step. They will take your overall health, medical history, lifestyle, and individual needs into consideration to recommend the most appropriate medication and dosage for you. The decision to use **sildenafil** or **avanafil** should be a collaborative effort between you and your provider, tailored to your specific circumstances. In conclusion, both **sildenafil** and **avanafil** are effective treatments for **erectile dysfunction** but they differ substantially in their onset, duration, side effects, and suitability for spontaneous activity. A careful review of their differences with the guidance of a healthcare professional ensures that you will make an informed choice that best fits your unique needs. 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While his specialty training was still in viagra side effects muscle pain progress, he took part in many complicated penile surgery operations and deepened his urology training with "andrological surgery training". Currently, Urology and Andrology Specialist Surgeon Evren IŞIK provides intensive services in the treatment of male-induced sexual dysfunctions and male-induced infertility, and also responds to the requests of male patients with genital male enhancement pills in sri lanka aesthetic demands. Performing his surgeries in contracted hospitals with advanced technology and high quality patient service in Izmir, Istanbul and Ankara, Surgeon Evren IŞIK continues to be the first choice of many male patients in Turkey and abroad. Web: Instagram: You can contact us for an appointment: +90 535 644 34 30 You can send us an e-mail about your problems: [email protected]